Helapride (Levosulpiride 25mg)

Helapride (Levosulpiride 25mg) is a prokinetic and antipsychotic drug, primarily used to treat gastrointestinal and psychiatric disorders. It belongs to the class of benzamides and acts by modulating dopamine receptors (primarily D2 receptors).


Main Uses of Helapride (Levosulpiride 25mg):

🔹 Gastrointestinal Uses (most common):

  1. Functional Dyspepsia (Indigestion):

    • Relieves bloating, fullness, nausea, and upper abdominal discomfort.

  2. Gastroesophageal Reflux Disease (GERD):

    • Improves gastric motility and reduces acid reflux by enhancing stomach emptying.

  3. Irritable Bowel Syndrome (IBS):

    • Especially useful in IBS with predominant bloating and upper GI symptoms.

  4. Gastroparesis:

    • Helps treat delayed stomach emptying, often seen in diabetics.

🔹 Psychiatric Uses:

  1. Depression with Somatic Symptoms:

    • Occasionally used to manage mild depression, anxiety, or psychosomatic disorders.

  2. Schizophrenia (less common):

    • As an antipsychotic, used in select cases, especially in low doses for negative symptoms.


🧠 How It Works:

Helapride (Levosulpiride 25mg) blocks dopamine D2 receptors, mainly in the gut (to improve motility) and the brain (to affect mood and behavior).